Investors

MPM Capital L.P.

MPM Capital L.P. is a global investment management firm focused solely on life sciences investing. One of the largest investment management firms dedicated to the life sciences sector, MPM Capital has offices in Boston and San Francisco. MPM's portfolio ranges from start-ups to large capitalization public companies, with a primary focus on biopharmaceutical and medical device companies nearing commercialization of products or those companies that already offer product-driven opportunities. The firm manages over $2.1 billion in assets through the MPM BioVentures Family of venture capital funds and the MPM BioEquities public market funds. More information on MPM can be found at www.MPMCapital.com.

OrbiMed Advisors, LLC

OrbiMed invests across the entire spectrum of pharmaceutical and biotechnology companies on a worldwide basis. Investments are made in hedge funds, private equity funds and other investment vehicles. OrbiMed's investment team has been active in private equity since 1993 and public equity since 1989. OrbiMed currently manages over $5.0 billion in assets, ranking the firm as one of the largest investment management firms focused solely on life sciences investing. OrbiMed maintains offices in New York City. More information on Orbimed can be found at www.orbimed.com.

Panorama Capital, LLC

Panorama Capital was established in late 2005 by the investment team that currently manages the venture capital practice of JPMorgan Partners. The Panorama team is comprised of 16 seasoned investment professionals who currently manage an $800 million portfolio of development-stage life sciences and technology companies. Panorama Capital is located in Menlo Park, California. For more detail on the firm's activities, please visit www.panoramacapital.com.